@article{THESIS,
      recid = {11354},
      author = {Lee, Christopher William},
      title = {Reciprocal Regulation of Cell Signaling by Reactive  Central Glycolytic Metabolites},
      publisher = {University of Chicago},
      school = {Ph.D.},
      address = {2024-03},
      number = {THESIS},
      pages = {206},
      abstract = {Metabolism, a fundamental aspect of all biological  systems, encompasses the intricate network of chemical  reactions that occur within a living organism to maintain  life. Metabolism interconnects a broad range of crucial  biological processes including energy production, cellular  repair, growth, and response to environmental changes. The  study of metabolism not only provides insights into basic  biological functions but also aids in understanding and  treating metabolic disorders and diseases like cancer,  diabetes, aging, and obesity. As a reflection of the  diverse aspects of metabolism, this thesis outlines a  variety of studies centered around regulatory signaling  pathways that arise from reactive metabolites of the  central, highly conserved glycolytic pathway to understand  both fundamental aspects of cellular metabolism and disease  mechanisms. It delves into the dynamics of  3-phosphoglyceryl-lysine (pgK) modifications in  cyanobacteria, highlighting their oscillation in response  to environmental light/dark cycles and impact on glycolytic  enzymes and central carbon metabolism flux. It confirms the  role of DJ-1 in detoxifying methylglyoxal as a glyoxalase,  to set the foundation for future pathophysiological studies  of the metabolism of neurodegenerative disorders.  Furthermore, it explores the potential of histone  deacetylases, specifically HDAC3, in regulating pgK  modifications, and suggests potential research directions  to study the broader functional implications of this  mechanism. Lastly, this thesis maps how cancer cells  respond to glycolytic perturbations, focusing in particular  on the relationship between different forms of central  glycolytic perturbation and the resulting stress responses;  highlighting especially the role of central glycolysis as a  nexus for redox stress signaling. Overall, this thesis aims  to present findings that offer new insights into metabolic  regulation and disease pathology by reactive metabolite  post-translational modifications, with the goal of  improving insight for next generation therapeutic  approaches against metabolically aberrant diseases.},
      url = {http://knowledge.uchicago.edu/record/11354},
      doi = {https://doi.org/10.6082/uchicago.11354},
}