@article{TEXTUAL,
      recid = {11316},
      author = {Luo, Taokun and Jiang, Xiaomin and Li, Jinhong and Nash,  Geoffrey T. and Yuan, Eric and Albano, Luciana and Tillman,  Langston and Lin, Wenbin},
      title = {Phosphate Coordination to Metal-Organic Layer Secondary  Building Units Prolongs Drug Retention for Synergistic  Chemoradiotherapy},
      journal = {Angewandte Chemie International Edition},
      address = {2024-02-21},
      number = {TEXTUAL},
      abstract = {Chemoradiotherapy combines radiotherapy with concurrent  chemotherapy to potentiate antitumor activity but  exacerbates toxicities and causes debilitating side effects  in cancer patients. Herein, we report the use of a  nanoscale metal-organic layer (MOL) as a 2D  nanoradiosensitizer and a reservoir for the slow release of  chemotherapeutics to amplify the antitumor effects of  radiotherapy. Coordination of phosphate-containing drugs to  MOL secondary building units prolongs their intratumoral  retention, allowing for continuous release of gemcitabine  monophosphate (GMP) for effective localized chemotherapy.  In the meantime, the MOL sensitizes cancer cells to X-ray  irradiation and provides potent radiotherapeutic effects.  GMP-loaded MOL (GMP/MOL) enhances cytotoxicity by 2-fold  and improves radiotherapeutic effects over free GMP in  vitro. In a colon cancer model, GMP/MOL retains GMP in  tumors for more than four days and, when combined with  low-dose radiotherapy, inhibits tumor growth by 98 %. The  synergistic chemoradiotherapy enabled by GMP/MOL shows a  cure rate of 50 %, improves survival, and ameliorates  cancer-proliferation histological biomarkers.},
      url = {http://knowledge.uchicago.edu/record/11316},
}