@article{TEXTUAL,
      recid = {11126},
      author = {Parzen-Johnson, Simon and Katz, Ben Z.},
      title = {Navigating the Spectrum of Two Pediatric COVID-19  Complications: Multi-System Inflammatory Syndrome in  Children and Post-Acute Sequelae of SARS-CoV-2 Infection},
      journal = {Journal of Clinical Medicine},
      address = {2024-02-18},
      number = {TEXTUAL},
      abstract = {Purpose: This review summarizes the current scope of  understanding associated with two common post-infectious  complications associated with COVID-19 infection:  Multi-System Inflammatory Syndrome in Children (MIS-C) and  Post-Acute Sequelae of SARS-CoV-2 infection (PASC). It  identifies current gaps in the knowledge and issues that  may limit the ability to fill these gaps. This review  provides a framework to drive continued research. Methods:  A comprehensive review of the current literature was  performed, identifying seminal articles describing the  emergence of MIS-C and PASC, and works from the literature  focused on the clinical implications and pathophysiologic  understanding of these disorders. Findings: Although  pediatric patients experienced few severe cases of acute  COVID-19 infection, the burden of disease from  post-infectious sequelae is substantial. Mortality is low,  but morbidity is significant. There are still numerous  unknowns about the pathophysiology of both MIS-C and PASC;  however, with widespread immunity developing after  increased vaccination and prior infection, it may be  difficult to perform adequate prospective studies to answer  pathophysiologic questions. Long-term sequalae of MIS-C  seem to be minimal whereas, by definition, PASC is an  ongoing problem and may be severe. Implications: The rapid  sharing of information regarding novel conditions such as  MIS-C and PASC are key to interventions related to future  post-infectious sequelae outside of those stemming from  COVID-19. Although MIS-C seems unlikely to return as a  clinical condition in substantial numbers, there is still  significant learning that can be gleaned from existing  patients about general aspects of epidemiology, equity, and  pathophysiology. There is significant morbidity associated  with PASC and additional resources need to be dedicated to  determining appropriate and effective therapies moving  forward.},
      url = {http://knowledge.uchicago.edu/record/11126},
}