@article{TEXTUAL,
      recid = {11106},
      author = {Farris, Kathryn M. and Senior, Alistair M. and Sobreira,  Débora R. and Mitchell, Robert M. and Weber, Zachary T. and  Ingerslev, Lars R. and Barrès, Romain and Simpson, Stephen  J. and Crean, Angela J. and Nobrega, Marcelo A.},
      title = {Dietary macronutrient composition impacts gene regulation  in adipose tissue},
      journal = {Communications Biology},
      address = {2024-02-16},
      number = {TEXTUAL},
      abstract = {Diet is a key lifestyle component that influences  metabolic health through several factors, including total  energy intake and macronutrient composition. While the  impact of caloric intake on gene expression and  physiological phenomena in various tissues is well  described, the influence of dietary macronutrient  composition on these parameters is less well studied. Here,  we use the Nutritional Geometry framework to investigate  the role of macronutrient composition on metabolic function  and gene regulation in adipose tissue. Using ten isocaloric  diets that vary systematically in their proportion of  energy from fat, protein, and carbohydrates, we find that  gene expression and splicing are highly responsive to  macronutrient composition, with distinct sets of genes  regulated by different macronutrient interactions.  Specifically, the expression of many genes associated with  Bardet-Biedl syndrome is responsive to dietary fat content.  Splicing and expression changes occur in largely separate  gene sets, highlighting distinct mechanisms by which  dietary composition influences the transcriptome and  emphasizing the importance of considering splicing changes  to more fully capture the gene regulation response to  environmental changes such as diet. Our study provides  insight into the gene regulation plasticity of adipose  tissue in response to macronutrient composition, beyond the  already well-characterized response to caloric intake.},
      url = {http://knowledge.uchicago.edu/record/11106},
}