@article{TEXTUAL,
      recid = {11050},
      author = {Si, Youhui and Tian, Qiaomu and Zhao, Fan and Kelly, Sean  H. and Shores, Lucas S. and Camacho, Daniel F. and  Sperling, Anne I. and Andrade, Michael S. and Collier, Joel  H. and Chong, Anita S.},
      title = {Adjuvant-free nanofiber vaccine induces in situ lung  dendritic cell activation and TH17 responses},
      journal = {Science Advances},
      address = {2020-08-07},
      number = {TEXTUAL},
      abstract = {The current paradigm that subunit vaccines require  adjuvants to optimally activate innate immunity implies  that increased vaccine reactogenicity will invariably be  linked to improved immunogenicity. Countering this  paradigm, nanoparticulate vaccines have been reported to  act as delivery systems for vaccine antigens and induce  immunity without the need for exogenous adjuvants or local  inflammation; however, the mechanisms underlying the  immunogenicity of nanoparticle vaccines are incompletely  identified. Here, we show that antigens displayed on  self-assembling nanofiber scaffolds and delivered  intranasally are presented by CD103+ and CD11b+ lung  dendritic cells that up-regulate CD80 and migrate into the  draining lymph node (LN). This was accompanied by a nearly  exclusive priming and accumulation of antigen-specific TH17  cells occurring independently in both LN and lung. Thus,  self-assembling peptide nanofiber vaccines may represent a  novel, needle- and adjuvant-free means of eliciting  protective immunity against fungal and bacterial infections  at skin and mucosal barrier surfaces.},
      url = {http://knowledge.uchicago.edu/record/11050},
}