@article{TEXTUAL,
      recid = {10963},
      author = {Ni, Kaiyuan and Lan, Guangxu and Guo, Nining and Culbert,  August and Luo, Taokun and Wu, Tong and Weichselbaum, Ralph  R. and Lin, Wenbin},
      title = {Nanoscale metal-organic frameworks for x-ray activated in  situ cancer vaccination},
      journal = {Science Advances},
      address = {2020-10-02},
      number = {TEXTUAL},
      abstract = {Cancer vaccines have been actively pursued to bolster  antitumor immunity. Here, we designed nanoscale  metal-organic frameworks (nMOFs) as locally activable  immunotherapeutics to release danger-associated molecular  patterns (DAMPs) and tumor antigens and deliver  pathogen-associated molecular patterns (PAMPs) for in situ  personalized cancer vaccination. When activated by x-rays,  nMOFs effectively generate reactive oxygen species to  release DAMPs and tumor antigens while delivering CpG  oligodeoxynucleotides as PAMPs to facilitate the maturation  of antigen-presenting cells. Together, DAMPs, tumor  antigens, and PAMPs expand cytotoxic T cells in  tumor-draining lymph nodes to reinvigorate the adaptive  immune system for local tumor regression. When treated in  combination with an immune checkpoint inhibitor, the local  therapeutic effects of nMOF-based vaccines were extended to  distant tumors via attenuating T cell exhaustion. Our work  demonstrates the potential of nMOFs as x-ray-activable in  situ cancer vaccines to awaken the host's innate and  adaptive immune systems for systemic antitumor immunity.},
      url = {http://knowledge.uchicago.edu/record/10963},
}