@article{TEXTUAL,
recid = {10843},
author = {Tendler, Benjamin C. and Hanayik, Taylor and Ansorge, Olaf and Bangerter-Christensen, Sarah and Berns, Gregory S. and Bertelsen, Mads F. and Bryant, Katherine L. and Foxley, SEan and van den Heuvel, Martijn P. and Howard, Amy FD and Huszar, Istvan N. and Khrapitchev, Alexandre A. and Leonte, Anne and Manger, Paul R. and Menke, Ricarda AL and Mollink, Jeroen and Mortimer, Duncan and Pallebage-Gamarallage, Menuka and Roumazeilles, Lea and Sallet, Jerome},
title = {The Digital Brain Bank, an open access platform for post-mortem imaging datasets},
journal = {eLife},
address = {2022-03-17},
number = {TEXTUAL},
abstract = {<p class="paragraph">Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins of image contrast through microscopy comparisons. We introduce the&nbsp;<em>Digital Brain Bank</em>&nbsp;(<a href="https://open.win.ox.ac.uk/DigitalBrainBank/">open.win.ox.ac.uk/DigitalBrainBank</a>), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes<em>&mdash;Digital Neuroanatomist</em>: datasets for detailed neuroanatomical investigations;&nbsp;<em>Digital Brain Zoo</em>: datasets for comparative neuroanatomy; and&nbsp;<em>Digital Pathologist</em>: datasets for neuropathology investigations. The first&nbsp;<em>Digital Brain Bank</em>&nbsp;data release includes 21 distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen nonhuman primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. The&nbsp;<em>Digital Brain Bank</em>&nbsp;is the culmination of our lab&rsquo;s investment into post-mortem MRI methodology and MRI-microscopy analysis techniques. This manuscript provides a detailed overview of our work with post-mortem imaging to date, including the development of diffusion MRI methods to image large post-mortem samples, including whole, human brains. Taken together, the&nbsp;<em>Digital Brain Bank</em>&nbsp;provides cross-scale, cross-species datasets facilitating the incorporation of post-mortem data into neuroimaging studies.</p>},
url = {http://knowledge.uchicago.edu/record/10843},
}