@article{TEXTUAL,
      recid = {10673},
      author = {He, Zhengying and Eichel, Kelsie and Ruvinsky, Ilya},
      title = {Functional Conservation of  <i>Cis</i>-Regulatory Elements of Heat-Shock  Genes over Long Evolutionary Distances},
      journal = {PLOS ONE},
      address = {2011-07-25},
      number = {TEXTUAL},
      abstract = {<p>Transcriptional control of gene regulation is an  intricate process that requires precise orchestration of a  number of molecular components. Studying its evolution can  serve as a useful model for understanding how complex  molecular machines evolve. One way to investigate evolution  of transcriptional regulation is to test the functions of  <em>cis</em>-elements from one species in a distant  relative. Previous results suggested that few, if any,  tissue-specific promoters from Drosophila are faithfully  expressed in <em>C. elegans</em>. Here we show that, in  contrast, promoters of fly and human heat-shock genes are  upregulated in <em>C. elegans</em> upon exposure to heat.  Inducibility under conditions of heat shock may represent a  relatively simple “on-off” response, whereas complex  expression patterns require integration of multiple  signals. Our results suggest that simpler aspects of  regulatory logic may be retained over longer periods of  evolutionary time, while more complex ones may be diverging  more rapidly.</p>},
      url = {http://knowledge.uchicago.edu/record/10673},
}