000010588 001__ 10588
000010588 005__ 20250218124712.0
000010588 02470 $$ahttps://doi.org/10.1371/journal.pgen.1005111$$2doi
000010588 037__ $$aTEXTUAL
000010588 037__ $$bArticle
000010588 041__ $$aeng
000010588 245__ $$aHost Genetic Variation Influences Gene Expression Response to Rhinovirus Infection
000010588 269__ $$a2015-04-13
000010588 336__ $$aArticle
000010588 520__ $$a<p>Rhinovirus (RV) is the most prevalent human respiratory virus and is responsible for at least half of all common colds. RV infections may result in a broad spectrum of effects that range from asymptomatic infections to severe lower respiratory illnesses. The basis for inter-individual variation in the response to RV infection is not well understood. In this study, we explored whether host genetic variation is associated with variation in gene expression response to RV infections between individuals. To do so, we obtained genome-wide genotype and gene expression data in uninfected and RV-infected peripheral blood mononuclear cells (PBMCs) from 98 individuals. We mapped local and distant genetic variation that is associated with inter-individual differences in gene expression levels (eQTLs) in both uninfected and RV-infected cells. We focused specifically on response eQTLs (reQTLs), namely, genetic associations with inter-individual variation in gene expression response to RV infection. We identified local reQTLs for 38 genes, including genes with known functions in viral response (<em>UBA7</em>, <em>OAS1</em>, <em>IRF5</em>) and genes that have been associated with immune and RV-related diseases (e.g., <em>ITGA2</em>, <em>MSR1</em>, <em>GSTM3</em>). The putative regulatory regions of genes with reQTLs were enriched for binding sites of virus-activated STAT2, highlighting the role of condition-specific transcription factors in genotype-by-environment interactions. Overall, we suggest that the 38 loci associated with inter-individual variation in gene expression response to RV-infection represent promising candidates for affecting immune and RV-related respiratory diseases.</p>
000010588 536__ $$oNational Institutes of Health$$cR01 HL085197
000010588 536__ $$oNational Institutes of Health$$cP01 HL070831
000010588 536__ $$oNational Institutes of Health$$cU19 AI106683
000010588 536__ $$oNational Institutes of Health$$cR01 MH084703
000010588 540__ $$a<p>© 2015 Çalışkan et al.</p> <p>This is an open access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</p>
000010588 542__ $$fCC BY
000010588 594__ $$aGene expression data are available at the Gene Expression Omnibus (GEO accession number: GSE53543).
000010588 690__ $$aBiological Sciences Division
000010588 691__ $$aHuman Genetics
000010588 7001_ $$aÇalışkan, Minal$$uUniversity of Chicago
000010588 7001_ $$aBaker, Samuel W.$$uUniversity of Chicago
000010588 7001_ $$aGilad, Yoav$$uUniversity of Chicago
000010588 7001_ $$aOber, Carole$$uUniversity of Chicago
000010588 773__ $$tPLOS Genetics
000010588 8564_ $$yArticle$$920d30ab5-70d2-4dca-8979-c05f58614151$$s775490$$uhttps://knowledge.uchicago.edu/record/10588/files/journal.pgen.1005111.pdf$$ePublic
000010588 8564_ $$ySupporting information$$9d898e99f-bba9-4047-bb2e-95ac394466a5$$s16138688$$uhttps://knowledge.uchicago.edu/record/10588/files/journal.pgen.1005111.zip$$ePublic
000010588 908__ $$aI agree
000010588 909CO $$ooai:uchicago.tind.io:10588$$pGLOBAL_SET
000010588 983__ $$aArticle