@article{TEXTUAL,
      recid = {10588},
      author = {Çalışkan, Minal and Baker, Samuel W. and Gilad, Yoav and  Ober, Carole},
      title = {Host Genetic Variation Influences Gene Expression Response  to Rhinovirus Infection},
      journal = {PLOS Genetics},
      address = {2015-04-13},
      number = {TEXTUAL},
      abstract = {&lt;p&gt;Rhinovirus (RV) is the most prevalent human respiratory  virus and is responsible for at least half of all common  colds. RV infections may result in a broad spectrum of  effects that range from asymptomatic infections to severe  lower respiratory illnesses. The basis for inter-individual  variation in the response to RV infection is not well  understood. In this study, we explored whether host genetic  variation is associated with variation in gene expression  response to RV infections between individuals. To do so, we  obtained genome-wide genotype and gene expression data in  uninfected and RV-infected peripheral blood mononuclear  cells (PBMCs) from 98 individuals. We mapped local and  distant genetic variation that is associated with  inter-individual differences in gene expression levels  (eQTLs) in both uninfected and RV-infected cells. We  focused specifically on response eQTLs (reQTLs), namely,  genetic associations with inter-individual variation in  gene expression response to RV infection. We identified  local reQTLs for 38 genes, including genes with known  functions in viral response (&lt;em&gt;UBA7&lt;/em&gt;, &lt;em&gt;OAS1&lt;/em&gt;,  &lt;em&gt;IRF5&lt;/em&gt;) and genes that have been associated with  immune and RV-related diseases (e.g., &lt;em&gt;ITGA2&lt;/em&gt;,  &lt;em&gt;MSR1&lt;/em&gt;, &lt;em&gt;GSTM3&lt;/em&gt;). The putative regulatory  regions of genes with reQTLs were enriched for binding  sites of virus-activated STAT2, highlighting the role of  condition-specific transcription factors in  genotype-by-environment interactions. Overall, we suggest  that the 38 loci associated with inter-individual variation  in gene expression response to RV-infection represent  promising candidates for affecting immune and RV-related  respiratory diseases.&lt;/p&gt;},
      url = {http://knowledge.uchicago.edu/record/10588},
}