@article{TEXTUAL,
      recid = {10546},
      author = {Maresso, Anthony W. and Garufi, Gabriella and Schneewind,  Olaf},
      title = {&amp;lt;i&amp;gt;Bacillus anthracis&amp;lt;/i&amp;gt; Secretes Proteins  That Mediate Heme Acquisition from Hemoglobin},
      journal = {PLOS Pathology},
      address = {2008-08-22},
      number = {TEXTUAL},
      abstract = {&lt;p&gt;Acquisition of iron is necessary for the replication of  nearly all bacterial pathogens; however, iron of vertebrate  hosts is mostly sequestered by heme and bound to hemoglobin  within red blood cells. In &lt;em&gt;Bacillus anthracis&lt;/em&gt;, the  spore-forming agent of anthrax, the mechanisms of iron  scavenging from hemoglobin are unknown. We report here that  &lt;em&gt;B. anthracis&lt;/em&gt; secretes IsdX1 and IsdX2, two NEAT  domain proteins, to remove heme from hemoglobin, thereby  retrieving iron for bacterial growth. Unlike other  Gram-positive bacteria, which rely on cell wall anchored  Isd proteins for heme scavenging, &lt;em&gt;B. anthracis&lt;/em&gt;  seems to have also evolved NEAT domain proteins in the  extracellular milieu and in the bacterial envelope to  provide for the passage of heme.&lt;/p&gt;},
      url = {http://knowledge.uchicago.edu/record/10546},
}