@article{TEXTUAL,
      recid = {10542},
      author = {Aldinger, Kimberly A. and Sokoloff, Greta and Rosenberg,  David M. and Palmer, Abraham A. and Millen, Kathleen J.},
      title = {Genetic Variation and Population Substructure in Outbred  CD-1 Mice: Implications for Genome-Wide Association  Studies},
      journal = {PLOS ONE},
      address = {2009-03-06},
      number = {TEXTUAL},
      abstract = {<p>Outbred laboratory mouse populations are widely used in  biomedical research. Since little is known about the degree  of genetic variation present in these populations, they are  not widely used for genetic studies. Commercially available  outbred CD-1 mice are drawn from an extremely large  breeding population that has accumulated many recombination  events, which is desirable for genome-wide association  studies. We therefore examined the degree of genome-wide  variation within CD-1 mice to investigate their suitability  for genetic studies. The CD-1 mouse genome displays  patterns of linkage disequilibrium and heterogeneity  similar to wild-caught mice. Population substructure and  phenotypic differences were observed among CD-1 mice  obtained from different breeding facilities. Differences in  genetic variation among CD-1 mice from distinct facilities  were similar to genetic differences detected between  closely related human populations, consistent with a  founder effect. This first large-scale genetic analysis of  the outbred CD-1 mouse strain provides important  considerations for the design and analysis of genetic  studies in CD-1 mice.</p>},
      url = {http://knowledge.uchicago.edu/record/10542},
}