@article{TEXTUAL,
      recid = {10410},
      author = {Cohen, Jarish N. and Tewalt, Eric F. and Rouhani, Sherin  J. and Buonomo, Erica L. and Bruce, Amber N. and Xu,  Xiaojiang and Bekiranov, Stefan and Fu, Yang-Xin and  Engelhard, Victor H.},
      title = {Tolerogenic Properties of Lymphatic Endothelial Cells Are  Controlled by the Lymph Node Microenvironment},
      journal = {PLOS ONE},
      address = {2014-02-04},
      number = {TEXTUAL},
      abstract = {<p>Peripheral self-tolerance eliminates lymphocytes  specific for tissue-specific antigens not encountered in  the thymus. Recently, we demonstrated that lymphatic  endothelial cells in mice directly express peripheral  tissue antigens, including tyrosinase, and induce deletion  of specific CD8 T cells via Programmed Death Ligand-1  (PD-L1). Here, we demonstrate that high-level expression of  peripheral tissue antigens and PD-L1 is confined to  lymphatic endothelial cells in lymph nodes, as opposed to  tissue (diaphragm and colon) lymphatics. Lymphatic  endothelial cells in the lymph node medullary sinus express  the highest levels of peripheral tissue antigens and PD-L1,  and are the only subpopulation that expresses tyrosinase  epitope. The representation of lymphatic endothelial cells  in the medullary sinus expressing high-level PD-L1, which  is necessary for normal CD8 T cell deletion kinetics, is  controlled by lymphotoxin-β receptor signaling and B cells.  Lymphatic endothelial cells from neonatal mice do not  express high-level PD-L1 or present tyrosinase epitope.  This work uncovers a critical role for the lymph node  microenvironment in endowing lymphatic endothelial cells  with potent tolerogenic properties.</p>},
      url = {http://knowledge.uchicago.edu/record/10410},
}