@article{TEXTUAL,
      recid = {10403},
      author = {Fang, Shu and Yukilevich, Roman and Chen, Ying and  Turissini, David A. and Zeng, Kai and Boussy, Ian A. and  Wu, Chung-I.},
      title = {Incompatibility and Competitive Exclusion of Genomic  Segments between Sibling &amp;lt;i&amp;gt;Drosophila&amp;lt;/i&amp;gt;  Species},
      journal = {PLOS Genetics},
      address = {2012-06-28},
      number = {TEXTUAL},
      abstract = {&lt;p&gt;The extent and nature of genetic incompatibilities  between incipient races and sibling species is of  fundamental importance to our view of speciation. However,  with the exception of hybrid inviability and sterility  factors, little is known about the extent of other, more  subtle genetic incompatibilities between incipient species.  Here we experimentally demonstrate the prevalence of such  genetic incompatibilities between two young allopatric  sibling species, &lt;em&gt;Drosophila simulans&lt;/em&gt; and &lt;em&gt;D.  sechellia&lt;/em&gt;. Our experiments took advantage of 12  introgression lines that carried random introgressed &lt;em&gt;D.  sechellia&lt;/em&gt; segments in different parts of the &lt;em&gt;D.  simulans&lt;/em&gt; genome. First, we found that these  introgression lines did not show any measurable sterility  or inviability effects. To study if these  &lt;em&gt;sechellia&lt;/em&gt; introgressions in a &lt;em&gt;simulans&lt;/em&gt;  background contained other fitness consequences, we  competed and genetically tracked the marked alleles within  each introgression against the wild-type alleles for 20  generations. Strikingly, all marked &lt;em&gt;D. sechellia&lt;/em&gt;  introgression alleles rapidly decreased in frequency in  only 6 to 7 generations. We then developed computer  simulations to model our competition results. These  simulations indicated that selection against &lt;em&gt;D.  sechellia&lt;/em&gt; introgression alleles was high (average  &lt;em&gt;s&lt;/em&gt; = 0.43) and that the marker alleles and the  incompatible alleles did not separate in 78% of the  introgressions. The latter result likely implies that most  introgressions contain multiple genetic incompatibilities.  Thus, this study reveals that, even at early stages of  speciation, many parts of the genome diverge to a point  where introducing foreign elements has detrimental fitness  consequences, but which cannot be seen using standard  sterility and inviability assays.&lt;/p&gt;},
      url = {http://knowledge.uchicago.edu/record/10403},
}