@article{TEXTUAL,
      recid = {10374},
      author = {Hu, Zheng and Fu, Yun-Xin and Greenberg, Anthony J. and  Wu, Chung-I and Zhai, Weiwei},
      title = {Age-Dependent Transition from Cell-Level to  Population-Level Control in Murine Intestinal Homeostasis  Revealed by Coalescence Analysis},
      journal = {PLOS Genetics},
      address = {2013-02-28},
      number = {TEXTUAL},
      abstract = {<p>In multi-cellular organisms, tissue homeostasis is  maintained by an exquisite balance between stem cell  proliferation and differentiation. This equilibrium can be  achieved either at the single cell level (a.k.a. cell  asymmetry), where stem cells follow strict asymmetric  divisions, or the population level (a.k.a. population  asymmetry), where gains and losses in individual stem cell  lineages are randomly distributed, but the net effect is  homeostasis. In the mature mouse intestinal crypt, previous  evidence has revealed a pattern of population asymmetry  through predominantly symmetric divisions of stem cells. In  this work, using population genetic theory together with  previously published crypt single-cell data obtained at  different mouse life stages, we reveal a strikingly dynamic  pattern of stem cell homeostatic control. We find that  single-cell asymmetric divisions are gradually replaced by  stochastic population-level asymmetry as the mouse matures  to adulthood. This lifelong process has important  developmental and evolutionary implications in  understanding how adult tissues maintain their homeostasis  integrating the trade-off between intrinsic and extrinsic  regulations.</p>},
      url = {http://knowledge.uchicago.edu/record/10374},
}