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000010370 005__ 20250218124658.0
000010370 02470 $$ahttps://doi.org/10.1371/journal.pone.0074641$$2doi
000010370 037__ $$aTEXTUAL
000010370 037__ $$bArticle
000010370 041__ $$aeng
000010370 245__ $$aMyc-Dependent Genome Instability and Lifespan in &lt;i&gt;Drosophila&lt;/i&gt;
000010370 269__ $$a2013-09-06
000010370 336__ $$aArticle
000010370 520__ $$a&lt;p&gt;The Myc family of transcription factors are key regulators of cell growth and proliferation that are dysregulated in a large number of human cancers. When overexpressed, Myc family proteins also cause genomic instability, a hallmark of both transformed and aging cells. Using an &lt;em&gt;in vivo lacZ&lt;/em&gt; mutation reporter, we show that overexpression of Myc in &lt;em&gt;Drosophila&lt;/em&gt; increases the frequency of large genome rearrangements associated with erroneous repair of DNA double-strand breaks (DSBs). In addition, we find that overexpression of Myc shortens adult lifespan and, conversely, that Myc haploinsufficiency reduces mutation load and extends lifespan. Our data provide the first evidence that Myc may act as a pro-aging factor, possibly through its ability to greatly increase genome instability.&lt;/p&gt;
000010370 536__ $$cAG17242
000010370 536__ $$oEinstein Shock Center$$cAG038072$$aPilot grant
000010370 540__ $$a&lt;p&gt;© 2013 Greer et al.&lt;/p&gt; &lt;p&gt;This is an open access article distributed under the terms of the &lt;a href="http://creativecommons.org/licenses/by/4.0/" target="_blank"&gt;Creative Commons Attribution License&lt;/a&gt;, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.&lt;/p&gt;
000010370 542__ $$fCC BY
000010370 690__ $$aBiological Sciences Division
000010370 691__ $$aHuman Genetics
000010370 7001_ $$aGreer, Christina$$uAlbert Einstein College of Medicine
000010370 7001_ $$aLee, Moonsook$$uAlbert Einstein College of Medicine
000010370 7001_ $$aWesterhof, Maaike$$uAlbert Einstein College of Medicine
000010370 7001_ $$aMilholland, Brandon$$uAlbert Einstein College of Medicine
000010370 7001_ $$aSpokony, Rebecca$$uUniversity of Chicago
000010370 7001_ $$aVijg, Jan$$uAlbert Einstein College of Medicine
000010370 7001_ $$aSecombe, Julie$$uAlbert Einstein College of Medicine
000010370 773__ $$tPLOS ONE
000010370 8564_ $$yArticle$$90ef754e2-3671-4f57-8075-3b3cc290edda$$s1375460$$uhttps://knowledge.uchicago.edu/record/10370/files/journal.pone.0074641.pdf$$ePublic
000010370 8564_ $$ySupporting information$$99be07c0c-4a30-43c5-b867-72201d4db0df$$s2455800$$uhttps://knowledge.uchicago.edu/record/10370/files/journal.pone.0074641.zip$$ePublic
000010370 908__ $$aI agree
000010370 909CO $$ooai:uchicago.tind.io:10370$$pGLOBAL_SET
000010370 983__ $$aArticle