@article{TEXTUAL,
      recid = {10326},
      author = {Oldenburg, Ian Antón and Hendricks, William D. and Handy,  Gregory and Shamardani, Kiarash and Bounds, Hayley A. and  Doiron, Brent and Adesnik, Hillel},
      title = {The logic of recurrent circuits in the primary visual  cortex},
      journal = {Nature Neuroscience},
      address = {2024-01-03},
      number = {TEXTUAL},
      abstract = {Recurrent cortical activity sculpts visual perception by  refining, amplifying or suppressing visual input. However,  the rules that govern the influence of recurrent activity  remain enigmatic. We used ensemble-specific two-photon  optogenetics in the mouse visual cortex to isolate the  impact of recurrent activity from external visual input. We  found that the spatial arrangement and the visual feature  preference of the stimulated ensemble and the neighboring  neurons jointly determine the net effect of recurrent  activity. Photoactivation of these ensembles drives  suppression in all cells beyond 30 µm but uniformly drives  activation in closer similarly tuned cells. In nonsimilarly  tuned cells, compact, cotuned ensembles drive net  suppression, while diffuse, cotuned ensembles drive  activation. Computational modeling suggests that highly  local recurrent excitatory connectivity and selective  convergence onto inhibitory neurons explain these effects.  Our findings reveal a straightforward logic in which space  and feature preference of cortical ensembles determine  their impact on local recurrent activity.},
      url = {http://knowledge.uchicago.edu/record/10326},
}