@article{TEXTUAL,
      recid = {10302},
      author = {Yang, Shuang and Arguello, J. Roman and Li, Xin and Ding,  Yun and Zhou, Qi and Chen, Ying and Zhang, Yue and Zhao,  Ruoping and Brunet, Frédéric and Peng, Lixin and Long,  Manyuan and Wang, Wen},
      title = {Repetitive Element-Mediated Recombination as a Mechanism  for New Gene Origination in <i>Drosophila</i>},
      journal = {PLOS Genetics},
      address = {2008-01-18},
      number = {TEXTUAL},
      abstract = {<p>Previous studies of repetitive elements (REs) have  implicated a mechanistic role in generating new chimerical  genes. Such examples are consistent with the classic model  for exon shuffling, which relies on non-homologous  recombination. However, recent data for chromosomal  aberrations in model organisms suggest that ectopic  homology-dependent recombination may also be important.  Lack of a dataset comprising experimentally verified young  duplicates has hampered an effective examination of these  models as well as an investigation of sequence features  that mediate the rearrangements. Here we use ∼7,000 cDNA  probes (∼112,000 primary images) to screen eight species  within the <span class="genus-species">Drosophila  melanogaster</span> subgroup and identify 17 duplicates  that were generated through ectopic recombination within  the last 12 mys. Most of these are functional and have  evolved divergent expression patterns and novel chimeric  structures. Examination of their flanking sequences  revealed an excess of repetitive sequences, with the  majority belonging to the transposable element DNAREP1  family, associated with the new genes. Our dataset strongly  suggests an important role for REs in the generation of  chimeric genes within these species.</p>},
      url = {http://knowledge.uchicago.edu/record/10302},
}