@article{TEXTUAL,
      recid = {10297},
      author = {Coop, Graham and Myers, Simon R},
      title = {Live Hot, Die Young: Transmission Distortion in  Recombination Hotspots},
      journal = {PLOS Genetics},
      address = {2007-03-09},
      number = {TEXTUAL},
      abstract = {<p>There is strong evidence that hotspots of meiotic  recombination in humans are transient features of the  genome. For example, hotspot locations are not shared  between human and chimpanzee. Biased gene conversion in  favor of alleles that locally disrupt hotspots is a  possible explanation of the short lifespan of hotspots. We  investigate the implications of such a bias on human  hotspots and their evolution. Our results demonstrate that  gene conversion bias is a sufficiently strong force to  produce the observed lack of sharing of intense hotspots  between species, although sharing may be much more common  for weaker hotspots. We investigate models of how hotspots  arise, and find that only models in which hotspot alleles  do not initially experience drive are consistent with  observations of rather hot hotspots in the human genome.  Mutations acting against drive cannot successfully  introduce such hotspots into the population, even if there  is direct selection for higher recombination rates, such as  to ensure correct segregation during meiosis. We explore  the impact of hotspot alleles on patterns of haplotype  variation, and show that such alleles mask their presence  in population genetic data, making them difficult to  detect.</p>},
      url = {http://knowledge.uchicago.edu/record/10297},
}