@article{TEXTUAL,
      recid = {10233},
      author = {Hagmann, Jörg and Becker, Claude and Müller, Jonas and  Stegle, Oliver and Meyer, Rhonda C. and Wang, George and  Schneeberger, Korbinian and Fitz, Joffrey and Altmann,  Thomas and Bergelson, Joy and Borgwardt, Karsten and  Weigel, Detlef},
      title = {Century-scale Methylome Stability in a Recently Diverged  <i>Arabidopsis thaliana</i> Lineage},
      journal = {PLOS Genetics},
      address = {2015-01-08},
      number = {TEXTUAL},
      abstract = {<p>There has been much excitement about the possibility  that exposure to specific environments can induce an  ecological memory in the form of whole-sale, genome-wide  epigenetic changes that are maintained over many  generations. In the model plant <em>Arabidopsis  thaliana</em>, numerous heritable DNA methylation  differences have been identified in greenhouse-grown  isogenic lines, but it remains unknown how natural, highly  variable environments affect the rate and spectrum of such  changes. Here we present detailed methylome analyses in a  geographically dispersed <em>A. thaliana</em> population  that constitutes a collection of near-isogenic lines,  diverged for at least a century from a common ancestor.  Methylome variation largely reflected genetic distance, and  was in many aspects similar to that of lines raised in  uniform conditions. Thus, even when plants are grown in  varying and diverse natural sites, genome-wide epigenetic  variation accumulates mostly in a clock-like manner, and  epigenetic divergence thus parallels the pattern of  genome-wide DNA sequence divergence.</p>},
      url = {http://knowledge.uchicago.edu/record/10233},
}