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1.
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Hepatic steatosis is a major etiological factor in hepatocellular carcinoma (HCC), but factors causing lipid accumulation leading to HCC are not understood. We identify B [...]
12 October 2022 |
Ben May Department for Cancer Research; Cancer Biology; Molecular Metabolism and Nutrition |
Article |
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2.
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The development of the brain, as well as mood and cognitive functions, are affected by thyroid hormone (TH) signaling. Neurons are the critical cellular target for TH act [...]
19 May 2023 |
Medicine; Molecular Metabolism and Nutrition |
Article |
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3.
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Non-healing wounds have a negative impact on quality of life and account for many cases of amputation and even early death among patients. Diabetic patients are the predo [...]
11 September 2023 |
Cancer Biology; Immunology; Molecular Metabolism and Nutrition |
Article |
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4.
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The disclosure provides methods of preventing or treating metabolic syndrome in a subject by administering an effective amount of an inhibitor of laminin α4 expression, [...]
03 August 2017 |
Molecular Metabolism and Nutrition; Medicine |
Patent |
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5.
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Methods and compositions to suppress renin expression and blood pressure in mammals are disclosed. Vitamin D and its analogues and derivatives, including Gemini compounds [...]
02 September 2010 |
Medicine; Molecular Metabolism and Nutrition |
Patent |
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6.
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<p>Brown adipose tissue (BAT) generates heat during adaptive thermogenesis through a combination of oxidative metabolism and uncoupling protein 1-mediated electron [...]
04 July 2013 |
Molecular Metabolism and Nutrition |
Article |
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7.
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The invention provides methods and compositions for the treatment of inflammatory disorders, such as inflammatory bowel diseases (IBDs). The use of bacteria-free, probiot [...]
31 May 2007 |
Molecular Metabolism and Nutrition; Microbiology; Immunology; Medicine |
Patent |
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8.
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The invention provides an isolated, anti-inflammatory, cytoprotective compound that is soluble in aqueous fluid, is derivable from the conditioned medium of a probiotic c [...]
07 June 2007 |
Molecular Metabolism and Nutrition; Microbiology; Immunology; Medicine |
Patent |
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9.
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Provided herein are compositions and methods for treating and/or preventing pathogenic fungal infection and for maintenance of microbiome commensalism. In particular, pro [...]
27 February 2020 |
Molecular Metabolism and Nutrition; Microbiology; Immunology; Medicine |
Patent |
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10.
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Circadian rhythms govern glucose homeostasis, and their dysregulation leads to complex metabolic diseases. Gut microbes exhibit diurnal rhythms that influence host circad [...]
15 September 2023 |
Medicine; Molecular Metabolism and Nutrition |
Article |
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11.
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Atherosclerosis, a complex vascular disease, is increasingly recognized as an immunometabolic disorder due to the intricate interplay between inflammatory cytokines, bloo [...]
2023-08 |
Molecular Metabolism and Nutrition |
Dissertation |
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12.
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Glycogen storage in brown adipose tissue (BAT) is generally thought to take place through passive, substrate-driven activation of glycogenesis rather than programmatic sh [...]
23 May 2016 |
Medicine; Molecular Metabolism and Nutrition |
Article |
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13.
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Mechano-transduction mechanisms are instrumental to embryogenesis, tissue homeostasis, and disease pathologies. This is especially important in the vasculature, where loc [...]
2023-06 |
Molecular Metabolism and Nutrition |
Dissertation |
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14.
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The gut microbiota affects hepatic drug metabolism. However, gut microbial factors modulating hepatic drug metabolism are largely unknown. In this study, using a mouse mo [...]
11 July 2023 |
Medicine; Molecular Metabolism and Nutrition |
Article |
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15.
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Acetaminophen (APAP) is a commonly used analgesic and antipyretic that can cause hepatotoxicity due to production of toxic metabolites via cytochrome P450 (Cyp) 1a2 and C [...]
23 August 2017 |
Medicine; Molecular Metabolism and Nutrition |
Article |
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16.
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Metabolic diseases, including type 2 diabetes and cardiovascular disease, are a worsening epidemic, affecting millions of people worldwide. These disorders are complex an [...]
2022-12 |
Molecular Metabolism and Nutrition |
Dissertation |
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17.
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The clinical availability of tissue-specific biomarkers of thyroid hormone (TH) action constitutes a “holy grail” for the field. Scientists have investigated several [...]
27 October 2022 |
Molecular Metabolism and Nutrition |
Article |
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18.
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During the past several decades, the prevalence of obesity and related metabolic diseases has reached epidemic scale across the world. While obesity alone heavily impacts [...]
2022-08 |
Molecular Metabolism and Nutrition |
Dissertation |
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19.
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The US prevalence of obesity has risen from less than 20% to over 40% in last the 25 years despite all efforts to control it. Obesity represents a major health challenge [...]
2021-12 |
Molecular Metabolism and Nutrition |
Dissertation |
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20.
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The rate of obesity increased dramatically over the course of the last half century. In the United States, non-Hispanic black women have experienced a particularly high r [...]
2020-12 |
Molecular Metabolism and Nutrition |
Dissertation |
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21.
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Obesity rates have been climbing steadily for the past hundred years, and in conjunction so have the rates of many metabolic disease. The reasons for this are both comple [...]
2020-12 |
Molecular Metabolism and Nutrition |
Dissertation |
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22.
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While genome-wide association studies (GWAS) have identified variants and genes associated with human disease, a comprehensive understanding of the genetic architecture o [...]
2020-12 |
Molecular Metabolism and Nutrition |
Dissertation |
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23.
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Insulin resistance and type 2 diabetes have reached epidemic levels in the United States. Mouse models have demonstrated that the increase in inflammatory cytokines durin [...]
2020-12 |
Molecular Metabolism and Nutrition |
Dissertation |
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24.
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Type 2 diabetes disproportionately afflicts African-Americans, Latinx communities, and people with low income in the U.S. due to complex environmental influences. Despite [...]
2019-08 |
Molecular Metabolism and Nutrition |
Dissertation |
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25.
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The Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) is a nuclear corepressor that regulates the transcriptional activity of many transcription factors [...]
2019-08 |
Molecular Metabolism and Nutrition |
Dissertation |
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