1.
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Infected and malignant target-cells trigger Vγ9Vδ2 T cell activation by signaling pathogenic intracellular metabolite accumulation through Butyrophilin (BTN)-3A1 and BT [...]
2024-03 |
Interdisciplinary Scientist Training Program |
Dissertation |
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2.
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mRNA and protein clump—or condense—in response to cellular stress across the tree of eukaryotic life. Yet, despite decades of inquiry and its universal evolutionary c [...]
2023-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
3.
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Much remains unknown about the role of gut microbes in the development of a functional enteric nervous system (ENS), a network of neurons and glia within the gastrointest [...]
2023-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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4.
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The mammalian gut microbiome is a powerful and clinically relevant system to study processes of microbial adaptation, as it is a highly dynamic ecosystem that plays a wid [...]
2023-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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5.
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Potassium channels are membrane proteins critical for electrochemical regulation and function in almost all animal cells. In humans, many diseases are associated with mut [...]
2023-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
6.
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Nicotine is the main addictive component in cigarettes. After chronic exposure to nicotine, neural adaptations in key brain areas lead to an aversive state upon withdrawa [...]
2023-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
7.
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Despite the need for sentinel cells to respond to temporally evolving pathogenic and host signals, it is still unclear whether memory of previous signals shapes the respo [...]
2023-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
8.
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Across all stages of life, infants are amongst the most susceptible to brain injury. This vulnerability is particularly pronounced in a condition called Hypoxic Ischemic [...]
2023-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
9.
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Uncovering information hidden within brain networks can be a daunting task, especially in the cases of abnormal, disrupted neural networks, such as epilepsy. Here, I pres [...]
2023-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
10.
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<p>Dynamic and temporally specific gene regulatory changes may underlie unexplained genetic associations with complex disease. During a dynamic process such as cell [...]
21 January 2022 |
Human Genetics; Interdisciplinary Scientist Training Program |
Article |
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11.
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In both humans and mice, CD4+ T cells reactive to self-derived antigens have been implicated in a range of autoinflammatory processes. To promote disease, such cells must [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
12.
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The intestinal immune system facilitates nutrient absorption in the presence of diverse commensal microbiota while establishing a protective barrier to prevent infection. [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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13.
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Innate immune memory is a burgeoning field in immunology, yet there still remain many unanswered questions regarding its inherent duration in mitotic and post-mitotic cel [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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14.
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Precision Public Health is fundamentally focused on determining the right intervention for the right population at the right time in order to improve health outcomes. It [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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15.
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Chemical modifications on RNA play critical roles in gene expression regulation. Although recent advancements have allowed for significant elucidation of their functions, [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
16.
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Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has improved treatment options for patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). D [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
17.
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Genetic variation contributes greatly to differences between people, including differences in susceptibility to disease. A critical way that genetic variation influences [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
18.
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Cutaneous melanoma is a common cancer and cases have steadily increased since the mid 70s. For some patients, early diagnosis and surgical removal of melanomas is lifesav [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
19.
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Epilepsy is a neurological disorder characterized by recurrent, unprovoked seizures that produce a distinct signature of hypersynchronous neural activity in electroenceph [...]
2022-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
20.
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Whether or not a host organism mounts a protective immune response to invading pathogens is determined by a number of factors, including the genetic makeup of the host. H [...]
2022-06 |
Interdisciplinary Scientist Training Program |
Dissertation |
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21.
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Protein S-acylation, an enzymatically modulated lipid post-translational modification, is frequent and consequential; at the cellular level, it regulates protein subcellu [...]
2021-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
22.
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Lupus Nephritis is a chronic inflammatory kidney disease that arises in the context of systemic lupus erythematosus (SLE). It is characterized by the deposition of immune [...]
2021-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
|
23.
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Primary sclerosing cholangitis (PSC) is an immune-mediated, cholestatic liver disease characterized by progressive fibrosis of the liver bile ducts. PSC patients have sig [...]
2021-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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24.
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Fundamentally, biological life depends on precise regulation of the expression of genetic information. Post-transcriptional RNA modifications are a major component of reg [...]
2021-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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25.
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Normalization is a canonical nonlinear computation that underlies multisensory integration, attention, and other sensory processing. In this computation, the response of [...]
2021-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
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