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1.
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The mouse model has been at the forefront of biomedical research and discovery for over a century, significantly advancing our understanding of disease. However, a fundam [...]
2024-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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2.
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CUX1 is a dose-dependent transcription factor frequently mutated or deleted in high-risk myeloid neoplasms. We sought to understand the function of CUX1 in hematopoiesis. [...]
2024-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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3.
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The rapid processing of visual information is essential for many human behaviors, such as playing sports and avoiding road hazards. These behaviors require the processing [...]
2024-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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4.
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γδ T cells occupy a unique immunological niche, bridging innate and adaptive immune function within a single cellular compartment. The lineage-defining γδ T cell rece [...]
2024-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
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5.
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Loss of all or part of chromosome 7 [-7/del(7q)] is recurrent in myeloid neoplasms and associated with a poor response to chemotherapy. Chromosome 7-encoded genes that dr [...]
2024-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
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6.
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In Chapter 1, we developed cell-free DNA (cfDNA) biomarkers. Standard-of-care for patients with localized muscle-invasive bladder cancer is neoadjuvant chemotherapy follo [...]
2024-06 |
Interdisciplinary Scientist Training Program |
Dissertation |
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7.
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While single-cell "omics" have been critical for the study of human disease, most of these approaches require tissue dissociation, losing important spatial info [...]
2024-06 |
Interdisciplinary Scientist Training Program |
Dissertation |
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8.
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Germinal center (GC) B cells segregate into three subsets that compartmentalize the antagonistic molecular programs of selection, proliferation, and somatic hypermutation [...]
2024-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
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9.
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Infected and malignant target-cells trigger Vγ9Vδ2 T cell activation by signaling pathogenic intracellular metabolite accumulation through Butyrophilin (BTN)-3A1 and BT [...]
2024-03 |
Interdisciplinary Scientist Training Program |
Dissertation |
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10.
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mRNA and protein clump—or condense—in response to cellular stress across the tree of eukaryotic life. Yet, despite decades of inquiry and its universal evolutionary c [...]
2023-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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11.
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Much remains unknown about the role of gut microbes in the development of a functional enteric nervous system (ENS), a network of neurons and glia within the gastrointest [...]
2023-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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12.
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The mammalian gut microbiome is a powerful and clinically relevant system to study processes of microbial adaptation, as it is a highly dynamic ecosystem that plays a wid [...]
2023-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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13.
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Potassium channels are membrane proteins critical for electrochemical regulation and function in almost all animal cells. In humans, many diseases are associated with mut [...]
2023-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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14.
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Nicotine is the main addictive component in cigarettes. After chronic exposure to nicotine, neural adaptations in key brain areas lead to an aversive state upon withdrawa [...]
2023-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
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15.
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Despite the need for sentinel cells to respond to temporally evolving pathogenic and host signals, it is still unclear whether memory of previous signals shapes the respo [...]
2023-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
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16.
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Across all stages of life, infants are amongst the most susceptible to brain injury. This vulnerability is particularly pronounced in a condition called Hypoxic Ischemic [...]
2023-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
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17.
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Uncovering information hidden within brain networks can be a daunting task, especially in the cases of abnormal, disrupted neural networks, such as epilepsy. Here, I pres [...]
2023-08 |
Interdisciplinary Scientist Training Program |
Dissertation |
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18.
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Dynamic and temporally specific gene regulatory changes may underlie unexplained genetic associations with complex disease. During a dynamic process such as cellular d [...]
21 January 2022 |
Human Genetics; Interdisciplinary Scientist Training Program |
Article |
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19.
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In both humans and mice, CD4+ T cells reactive to self-derived antigens have been implicated in a range of autoinflammatory processes. To promote disease, such cells must [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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20.
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The intestinal immune system facilitates nutrient absorption in the presence of diverse commensal microbiota while establishing a protective barrier to prevent infection. [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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21.
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Innate immune memory is a burgeoning field in immunology, yet there still remain many unanswered questions regarding its inherent duration in mitotic and post-mitotic cel [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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22.
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Precision Public Health is fundamentally focused on determining the right intervention for the right population at the right time in order to improve health outcomes. It [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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23.
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Chemical modifications on RNA play critical roles in gene expression regulation. Although recent advancements have allowed for significant elucidation of their functions, [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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24.
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Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has improved treatment options for patients with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). D [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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25.
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Genetic variation contributes greatly to differences between people, including differences in susceptibility to disease. A critical way that genetic variation influences [...]
2022-12 |
Interdisciplinary Scientist Training Program |
Dissertation |
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